Acute tubular necrosis
Introduction
Acute kidney injury is a common clinical problem in hospitals and particularly in ICUs. The two leading causes of acute kidney injury in hospitals are prerenal renal failure and acute tubular necrosis (ATN). Prerenal kidney failure due to poor renal perfusion with decrease in GFR and potesielt fast reversible upon correction of renal perfusion. Being perfusjonsvikten standing over longer ischemic damage of tubular cells arise and ATN occurs. ATN can also result from nefrotoksiner and sepsis and will not be off immediately reversible. Causes
Tubular cells have a very high metabolic activity as ion pumps are energy intensive. Although the kidney normally has a high blood flow (20-25% of the cardiac output goes to the kidneys) is the meddulære through bleeding vulnerable. Ischemia of tubular cells will lead to death, shedding of cells into tubules and acute decline in GFR. Nefrotoksiner may cause ATN by direct damage or influence of peritubulær circulation with ischemic injury of tubular cells as a result. Table of common causes of ATN:
Causes | Examples |
---|
Prerenal causes | Dehydration |
| Hypotension |
| Reduced circulating volume |
| Selective renal ischemia |
| NSAIDs |
| ACE inhibitors in combination with the above |
Sepsis | |
Nefrotoksiner | Aminoglycosides |
| Freedom of myoglobin and hemoglobin |
| Cisplatin |
| Iodine-containing X-ray contrast |
| Antiviral drugs |
|
Clinical presentation
Affected patients present with acute kidney injury with rapidly rising creatinine. Kidney failure can be both oligurisk and non-oligurisk Urinary Findings
Unlike the prerenal kidney failure where urine sediment classic will be normal and the patient acknowledges a concentrated urine with sodium reabsorbed patient will at ATN have a urinary sediment with abundant granular cylinders and tubulicellesylindre because shedding of dead tubule. By ATN will tubular function be affected and classical is fractional excretion of sodium high as signs of this. (Photo by ATN on urine microscopy). Histopathology
It is seen necrosis of epithelial cells in the tubules, interstitial hemorrhage and leukocyte infiltration Course and treatment
Treatment consists of discontinuation of nephrotoxic substances that are not essential for life and strive to restore renal perfusion. Tubule has a good potential to regenerate and the prognosis is good. Classic renal function be normal in 6-12 weeks after an episode with ATN, but chronic renal injury may be composed by severe episodes with ATN. Read more about acute tubular necrosis
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