Condyloma (LSIL/CIN1) of the uterine cervix.
Clinical story
A 34 years old female with a previous diagnosis of HSIL in a cervical smear showed papillomatous lesions on the portio. Because of suspected dysplasia, biopsies were taken.
Comments
Several small sections through a thickened, hyperplastic squamous epithelium are seen. In the upper half of the epithelium, vacuolization of the cytoplasm and enlarged, hyperchromatic, irregular nuclei (koilocytosis) are seen. In some cells, two nuclei can be observed. These changes are associated with HPV infection. The basal half of the epithelium is focally disorganized, with larger nuclei above the basal layer, but maturation is seen in the upper half.
Small areas show normal epithelium, both squamous and mucinous.
Learning goals
You should recognize an ordinary HPV-infection in the squamous epithelium and understand the implications for follow up and treatment, according to the different virus types.