Uterus with intramucosal, well differentiated endometrioid adenocarcinoma (Type I)
Clinical story
40 years old female with irregular menstrual bleeding during the last 6 months. Curettage showed adenocarcinoma in the endometrium. Admitted to hospital for hysterectomy.
Comments
Endometrium with tightly packed, atypical glands with only little intervening stroma. Many glands are situated “back to back”, have an irregular form or grow
in a cribriform pattern. The epithelium is clearly atypical with loss of polarization, pseudostratification and atypical nuclei. Few mitoses are found. Some glands contain mucous and leukocytes. No infiltration into the myometrium is seen. The basal layer of the glands is intact.
Learning goals
To recognize type I endometrial adenocarcinoma and understand its etiology, diagnosis, staging and prognosis.