Uterus with high grade adenocarcinoma, probably of serous type (Type II)
Clinical story
89 years old female with hypertension and cystocele. Uterine bleeding over several months. Admitted to the outpatient clinic for D&C, followed by hysterectomy.
Comments
Section through the uterine wall with an infiltrating tumor, extending deeply into the myometrium. In some areas tumor cells grow in solid masses, in other areas atypical glands with scalloped inner surface and hobnailing, as well as papillary structures are found. Tumor cells have high-grade atypia, with nuclei that show considerable pleomorphism and distinct nucleoli. Multiple mitotic figures are
seen.
Learning goals
To recognize type II endometrial adenocarcinoma and understand its etiology, diagnosis, staging and prognosis.