Uterus with serous endometrial intraepithelial carcinoma (SEIC)
Clinical story
77 year old woman with postmenopausal spotting. Ultrasound showed a uterine polypp, which was removed at D&C.
Comments
The section shows a polyp with several cysts and glands. Peripheral areas of the polyp have endometrial glands with a sylindric epithelium. Atypical changes are found in more central
and cystic, atrophic areas. The epithelium of several of the cystically dilated glands have a "ragged" appearance due to enlarged nuclei protruding "hob-nail"-like into the lumina.
Learning goals
To recognize atrophic changes in the endometrium and the appearance of in-situ changes of serous type. The growth pattern of serous atypia and the biological differences to hormonally driven pre-stages of type I cancers should also be acknowledged.