Ovary with serous adenocarcinoma, high grade

Clinical story

63 years old female with an abdominal tumor and large-volume ascites, discovered incidentally. Salpingo-oophorectomy and resection of part of the omentum majus.

Virtual microscopy of the slide

Comments

By gross examination, the ovary contains a partitioned cystic tumor,

approximately 10 cm in diameter and weighing 250 g. Papillary projections were present on the ovarian surface. Section from the ovary shows tumor growth in

the stroma and on the surface. The tumor has a partially papillary growth on the surface, with pseudostratified epithelium with many mitoses and significant atypia. In the stroma, the tumor grows with a more solid pattern. Cells have

overt atypia and multiple mitotic figures, some atypical.

Incidental findings are benign cysts in the ovarian stroma.

Learning goals

To recognize high-grade serous adenocarcinoma and understand its clinical significance and differences from low-grade serous adenocarcinoma.