Ovary with mature teratoma
Clinical story
18 years old female with right-sided abdominal pain. Removal of the right ovary with tumor. No peritoneal gliomatosis was found, and a blood sample proved negative for alpha-fetoprotein (AFP).
Comments
Grossly, cystically enlarged ovary, 11 cm in diameter. Cross-section showed multiple cavities filled with a gel-like matter. Section from the ovarian tumor.
Microscopy: lesion that is partly cystic, with a cavity containing keratin masses
and lined with squamous epithelium. Below the epithelium, sebaceous glands
and hair follicles are seen. In close proximity, nerve tissue with astrocytes and immature ganglion cells are seen. Retinal cells containing melanin are found in areas with cerebral differentiation. In other areas, differentiation in the
direction of smooth muscle tissue and of gastric mucosa, with a foveolar surface and regular oxyntic glands, are also present.
Learning goals
To recognize teratoma as a germ cell tumor; To identify its different components; To understand its potential to become malignant.