Ovary with granulosa cell tumor of adult type
Clinical story
55 years old female with endometrioid adenocarcinoma of the uterine corpus, probably well-differentiated, confirmed by curettage. Additionally, chronic lymphocytic leukemia. Hysterectomy, bilateral salpingo-oophorectomy and selective lymphadenectomy.
Comments
Grossly, thickened endometrium without definitive myometrial infiltration. Both adnexae evaluated as normal by gross examination.
Microscopy: A 1.2 cm solid tumor in the right ovary. Tumor cells form pseudo-rosettes (Call-Exner bodies). The cells contain moderate amounts of cytoplasm with round to oval nuclei, which in many contain a longitudinal groove (‘coffee-bean’ nuclei). No mitoses are found.
Learning goals
To recognize Granulosa cell tumor as a sex cord stromal tumor; To identify Call-Exner bodies; To understand the differential diagnosis of this tumor and its hormone-producing potential; To understand its potential to become malignant.