Ovary with Leydig cell tumor
Clinical story
57 years old female with abnormal hair growth and elevated testosterone levels. Clinically, a testosterone-producing ovarian tumor was suspected. Laparoscopy showed an enlarged left ovary, which was removed.
Comments
Gross appearance: enlarged ovary with a diameter of 5 cm. The ovary had a
lumpy surface. Sectioning showed a well demarcated lesion, 1.6 cm in diameter,
with a color of light to dark brown. Section from the left ovary.
Microscopy reveals ovarian cortex with multiple corpora albicantia and a circumscribed tumor, with cells with a low nuclear/cytoplasmic ratio. The cytoplasm is acidophilic, the nuclei mainly eccentrically located, vesicular and
with conspicuous nucleoli. Some cells are multinuclear. No mitoses are seen.
Learning goals
To recognize Leydig cell tumor as a sex cord stromal tumor; To understand its hormone-producing potential; To understand its clinical behavior.