OXIDATIVE STRESS AND ANTIOXIDANT PROTECTION

After following the lectures and completing the literature assignments and this e-lecture, you should:

• Be able to explain how oxidative damage appears and how antioxidants protect
• Have an overview of the biochemistry of vitamin E
• Know some importans aspects of vitamin E uptake and distribution in the body and how genetic defects of these functions may result in disease
• Know some important non-antioxidant functions of vitamin E, e.g. gene regulation and drug interaction
• Know what are the established roles of vitamin E in maintaining health, and in what areas more research is needed

Literature

• Shils et al., Modern nutrition in health and disease
• Duttaroy A et al. (1994) Vitamin E requirements, transport, and metabolism: Role of α-tocopherol-binding proteins J. Nutr. Biochem. 5, 562-570
• Azzi A (2004) : The role of α-tocopherol in preventing disease Eur. J. Nutr. 43, suppl. 1, 18-25