Animation - Nuclear Receptor

Nuclear receptor activation

The nuclear receptors of Type 2 are bound to their DNA response element (RE) as a heterodimer with retinoid X receptor (RXR).

1 In the absence of ligand, the nuclear receptors are bound to corepressor complexes that inhibit transcription.

2 The ligand binding leads to a conformational change of the receptors, which leads to dissociation of corepressors from the receptors.

3 The ligand binding also leads to recruitment of coactivator complexes and other protein complexes (general transcription factors) that are required for transcription of the target gene by RNA polymerase II (RNA Pol II).

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